Sunday, February 24, 2013

Relativity Moves 'Turkeys' Up a Year; Amy Poehler Joins Voice Cast (Exclusive)

NEW YORK (TheWrap.com) - Relativity Media has moved up its animated film "Turkeys" by a year and will release it November 1, multiple individuals close to the project told TheWrap. In addition, Amy Poehler has joined the voice cast for the film, which Relativity and Reel FX are co-producing and co-financing, TheWrap has learned.

The movie had been scheduled to debut November 14, 2014, but Relativity and Reel FX made the aggressive scheduling move based on early footage, according to two of those individuals. Development on the project began in June 2009 and physical production began in January 2011.

Poehler, who joins Owen Wilson and Woody Harrelson, will voice the female lead.

Executives at the studio met about the film this week, weighing the challenges the move will pose to the filmmaking, marketing, sponsorship and merchandising teams with the opportunity to seize this Thanksgiving's family market.

DreamWorks Animation recently moved "Mr. Peabody & Sherman" from November 1 to March 2014, opening the door for kid-friendly fare before the November 22 opening of "The Hunger Games: Catching Fire." Most of the other movies scheduled for October and November will cater to more mature audiences, spanning genres like science fiction ("Gravity," "Ender's Game"), horror ("Paranormal Activity 5," "Carrie") and action ("Malavita," "Thor: The Dark World").

Jeffrey Katzenberg's animation house has released a movie in the fall for eight of the last nine years, but its new distribution partner, Fox, moved "Peabody" to March, a month when the studio has had prior success with the "Ice Age" franchise.

DreamWorks Animation had a costly miss last November with "Rise of the Guardians," which grossed $301 million at the box office - a healthy sum, but not enough to cover costs. The company is expected to take a hefty write-down as a result in its upcoming fourth quarter earnings.

Reel FX, the Dallas-based animation and visual effects studio behind "Turkeys," actually sold "Guardians" to DWA five years ago.

"Turkeys" features the voices of Wilson and Harrelson as two spunky birds that take a time machine back to the first Thanksgiving. They want to expunge turkeys from Thanksgiving's culinary tradition. Lesley Nicol of "Downton Abbey," George Takei of "Star Trek" fame, Keith David and Colm Meaney have also been cast. Dan Fogler was already lending his voice.

Jimmy Hayward is directing the film from a script by Craig Mazin, David I. Stern, John J. Strauss.

Source: http://news.yahoo.com/relativity-moves-turkeys-amy-poehler-joins-voice-cast-010436508.html

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Saturday, February 23, 2013

Chesapeake fourth quarter profit tops Street, shares rise

(Reuters) - Chesapeake Energy Corp reported fourth-quarter profit that topped Wall Street estimates on Thursday, helped by lower-than-expected expenses and more profitable oil production.

Shares of Chesapeake rose nearly 2 percent to $20.60 before the start of regular trading.

The earnings report came a day after Chesapeake said an internal investigation of the financial dealings of its outgoing chief executive, Aubrey McClendon, found no "intentional" wrongdoing.

McClendon is stepping down in April following a tumultuous year during which the company faced a liquidity crunch and a governance crisis. Now Chesapeake's board and big shareholders are working to rein in spending, pay down debt and increase production of more profitable oil.

McClendon, who founded the company in 1989, was not quoted in the earnings release as he typically is.

Phil Weiss, an analyst with Argus Research, said expenses in a number of areas came in below his projections while cash flow was higher than he anticipated.

General and administrative expenses fell to $99 million in the quarter from $138 million a year earlier.

"Costs are moving in the right direction on both general and administrative and production expense," analysts at Tudor Pickering Holt & Co said in a note to clients.

The Oklahoma City, Oklahoma, company said profit fell to $257 million, or 39 cents per share, in the fourth quarter, from $429 million, or 63 cents per share, in the same period a year earlier.

Excluding items, Chesapeake's profit came to 26 cents per share. Analysts, on average, had expected 14 cents, according to Thomson Reuters I/B/E/S.

Chesapeake said production of crude oil and natural gas liquids rose 39 percent to 147,500 barrels per day, while overall output rose 9 percent.

The U.S. Securities and Exchange Commission is examining McClendon's financial transactions, while the Department of Justice and the attorney general in Michigan are investigating whether Chesapeake violated antitrust laws.

A series of Reuters investigations last year triggered civil and criminal probes into the second-largest U.S. producer of natural gas. Big shareholders Carl Icahn and Southeastern Asset Management took control of the board in June after McClendon was stripped of the chairman job.

(Editing by Jeffrey Benkoe)

Source: http://news.yahoo.com/chesapeake-energy-posts-lower-quarterly-profit-122221528--finance.html

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Friday, February 22, 2013

Mariah Carey Wants New Album Out 'ASAP'

The 'American Idol' judge reveals she's been hitting 'secret locations' to finish up the release.
By Jocelyn Vena


Mariah Carey
Photo: Christopher Polk/ Getty Images

Source: http://www.mtv.com/news/articles/1702351/mariah-carey-new-album-release.jhtml

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Winter storm blankets Great Plains with snow

ST. LOUIS (AP) ? Blinding snow, at times accompanied by thunder and lightning, bombarded much of the nation's midsection Thursday, causing whiteout conditions, shutting down large swaths of interstate highways and forcing schools, businesses and even state legislatures to close.

Kansas was the epicenter of the winter storm, with parts of the state buried under 14 inches of powdery snow, but winter storm warnings stretched from eastern Colorado through Illinois. Freezing rain and sleet were forecast for southern Missouri, southern Illinois and Arkansas. St. Louis received all of the above ? a treacherous mix of snow, sleet and freezing rain.

Several accidents were blamed on icy and slushy roadways, including two fatal accidents. Most schools in Kansas and Missouri, and many in neighboring states, were closed. Legislatures shut down in Kansas, Missouri, Arkansas, Nebraska and Iowa.

"Thundersnow" accompanied the winter storm in parts of Kansas and Missouri, which National Weather Service meteorologist Scott Truett said is the result of an unstable air mass, much like a thunderstorm.

"Instead of pouring rain, it's pouring snow," Truett said. And pouring was a sound description, with snow falling at a rate of 1 1/2 to 2 inches per hour in some spots. Kansas City, Mo., got 5 inches in two hours.

Snow totals passed the foot mark in many places: Monarch Pass, Colo., had 17 ? inches, Hutchinson, Kan., 14 inches and Wichita, Kan., 13 inches. The National Weather Service said up to 18 inches of snow were possible in central Kansas.

With that in mind, Kansas transportation officials ? and even the governor ? urged people to simply stay home.

Drivers were particularly warned away from the Kansas Turnpike, which had whiteout conditions. Interstate 70 was also snow-packed and a 90-mile stretch of that road was closed between Salina and Hays.

Kansas Gov. Sam Brownback closed executive offices, except for essential personnel.

"If you don't have to get out, just really, please, don't do it," Brownback said.

Travelers filled hotels rather than skating across dangerous roadways. At the Econo Lodge in WaKeeney, Kan., assistant manager Michael Tidball said the 48-room hotel was full by 10 p.m. Wednesday and that most guests were opting to stay an extra day.

Just south of Wichita, near the small community of Clearwater, Scott Van Allen had already shoveled the sidewalks Thursday and was out on his tractor clearing the driveway of the 10 inches of snow ? just in case he might need to go out. For once, he didn't mind the task.

"I kind of enjoyed it this time," he said. "We were certainly needing the moisture terribly."

The storm brought moisture to a region of the country that has been parched for nearly a year, engulfed in the worst drought in decades. Climatologists say 12 inches of snow is equivalent to about 1 inch of rain, depending on the density of the snow.

Vance Ehmke, a wheat farmer near Healy, Kan., said the nearly foot of snow was "what we have been praying for."

"The big question is, 'Is the drought broke?' " Ehmke asked. "We desperately need this."

Near Edwardsville, Ill., wheat farmer Mike Campbell called the snow ? or any precipitation ? a blessing after a bone-dry growing season in 2012. He hopes it is a good omen as he prepares to plant corn this spring.

"The corn was just a disaster," Campbell said.

In Colorado, the U.S. Forest Service planned to take advantage of the snow to burn piles of dead trees on federal land.

Near the Nebraska-Kansas border, as much as 8 inches fell overnight, while western Nebraska saw about half of that amount, National Weather Service forecaster Shawn Jacobs said.

Areas in western Oklahoma and the Texas Panhandle also had up to 8 inches of snow by Thursday morning. Christy Walker, a waitress at the Polly Anna Cafe in Woodward, Okla., got stuck on her drive into work. But business in the western Oklahoma town was brisk, she said.

"It's affecting everybody who is hungry and wants to come out to eat," she said. "I'm extremely busy right now."

Elsewhere, Arkansas saw a mix of precipitation ? in places, a combination of hail, sleet and freezing rain, others saw 6 inches of snow. Forecasters warned northern Arkansas could get a half-inch of ice.

Two fatal accidents were attributed to winter weather on Wednesday. In Oklahoma, 18-year-old Cody Alexander of Alex, Okla., died when his pickup truck skidded on a slushy state highway into oncoming traffic and struck a truck. And in Nebraska, 19-year-old Kristina Leigh Anne Allen of Callaway died when a SUV lost control in snowy, icy conditions, crossed the median and struck her car.

Missouri Gov. Jay Nixon declared a state of emergency Thursday morning and activated the State Emergency Operations Center. By midmorning Thursday, the snow was coming down so hard that Kansas City International Airport shut down. More than 200 flights were also canceled by Thursday afternoon at Lambert Airport in St. Louis.

Alex Sosnowski, a meteorologist for Accuweather, said the storm will push off into the Great Lakes and central Appalachians, and freezing rain could make it as far east and south as North Carolina. He also said a "spin-off" storm was expected to create heavy snow in New England, and could push Boston to a February record.

Accuweather said that by the time the storm dies out, at least 24 states will be affected.

___

Associated Press writers Chris Clark in Kansas City, Mo.; Jordan Shapiro in Columbia, Mo.; David A. Lieb in Jefferson City, Mo.; Josh Funk and Nelson Lampe in Omaha, Neb.; John Hanna in Topeka, Kan.; Roxana Hegeman in Wichita, Kan.; Tim Talley in Oklahoma City; David Warren in Dallas; Chuck Bartels in Little Rock, Ark.; Jim Suhr in St. Louis; and Steven K. Paulson in Denver contributed to this report.

Source: http://news.yahoo.com/winter-storm-blankets-great-plains-snow-153827825.html

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Washington University student overcomes testicular cancer

While his friends crammed for exams in the library, Brendan Ziebarth spent much of his fall attached to an IV.

It was an unconventional semester.

Ziebarth, 20, is an unconventional student. When doctors told him that his testicular cancer had returned, he opted to stay at Washington University to finish out the term.

?It really appealed to me to stay at school and be with my friends, the community at Wash. U, and people who I could hang out with who would really love and support me,? Ziebarth said. ?They would definitely be worrying about me if I were at home.?

Home is Arlington, Va., where Ziebarth was when he first discovered a hardening on his right testicle last June.

The urgent care center told him everything was fine. ?I insisted I got a referral to the urologist anyway,? Ziebarth said. ?Because I knew something was wrong.?

The urologist confirmed his fears ? it was testicular cancer ? and booked him for surgery the following Monday.

Ziebarth, whose friends gave him the moniker ?Ace? after the successful surgery, returned to St. Louis in good spirits, eager to continue his studies in architecture.

He went to monthly checkups at Barnes-Jewish. August looked good, but in September, he got a call back from the hospital.

The cancer had returned.

HIGH CURE RATE

As cancers go, testicular cancer is remarkably curable.

The five-year survival rate for all men with testicular cancer is 95 percent, according to the National Cancer Institute. If the illness remains isolated to the testicle, the rate is 99 percent.

Even if the cancer re-emerges in the nearby lymph nodes, as in Ziebarth?s case, the rate is still in the 90s.

?The odds were in my favor and I had a great team,? he said.

Ziebarth began chemotherapy treatment under Dr. Bruce Roth, a specialist at Siteman Cancer Center in genitourinary cancers.

The treatment came in four three-week cycles. On the first five days of each cycle, Ziebarth went in for six hours of treatment. On the ninth and 16th days, he went in for an hour.

He opted for IV treatment as opposed to a surgically implanted port. ?To me, it was less of a constant reminder that I was sick,? Ziebarth said.

Ziebarth?s team tailored his regimen to how his body responded to certain drugs and steroids, but he still felt the sickness brought on by chemotherapy.

?I had constant heartburn,? he said. ?I would be hungry, but then I wouldn?t want to eat because of the heartburn.?

On day eight of cycle two, Ziebarth came down with a fever and went to the emergency room. That night, he had a CT scan, an MRI, a spinal tap and numerous swabs and cultures. The doctors told Ziebarth he probably had a sinus infection.

?The other thing we learned was that I was having allergic reaction to the chemo drug Bleomycin. It gave me an excruciating migraine,? Ziebarth said. ?My dad has them frequently, and I learned to empathize because it was unbearable.

?That was sort of my darkest hour.?

A SOCIAL NETWORK

But Ziebarth said school work helped distract him from the realities of chemotherapy. The university worked with him to set up a lighter load of six credits.

?I was able to take my Intro to Sexuality Studies work with me to the hospital during treatment,? Ziebarth said. ?It was a lot of reading, but it was fascinating to me.?

He even tried Skyping into class from the hospital one day. ?It was really awkward talking about sex with all these other patients listening. I was in a room with seven other people who were getting treated, and they all tended to be in their sixth decade or so,? he said.

For the younger crowd, Ziebarth made a Facebook group so loved ones could receive updates on his health and know when to offer a helping hand. Friends raced to get Tylenol and volunteered to drive him to appointments, helping to relieve the burden on Ziebarth?s local family members.

And when Ziebarth lost his hair, one of his fraternity brothers ? in an impaired state ? decided to shave his in solidarity. Others soon followed.

?I thought it was great,? Ziebarth said. He told his friends that, when asked about their newly buzzed heads, they should use the opportunity to raise awareness about men?s cancers.

Figures like Lance Armstrong have boosted attention toward testicular cancer in recent years. ?Teenagers and young 20-year-olds are much more aware because of high profile cases,? said Roth, who was on the team that treated Armstrong at Indiana University.

Roth says it?s important to instruct potential patients on checking themselves because a yearly physical may be too infrequent to catch a growing mass.

And while his patients may be young, Roth also suggests that they think long term. ?We recommend to bank sperm for patients going under chemotherapy.? Roth said many testicular cancer patients already have lower sperm counts, and some are sterile.

427 LIKES

Ziebarth received his last chemotherapy treatment in Arlington over winter break.

It was Christmas Eve.

?I went out to dinner with my family to celebrate what we were pretty sure would be the last treatment, then we had Christmas and New Year?s,? he said. ?It was great to be home.?

He got the news he had been waiting for back in St. Louis. ?Dr. Roth did his job, cured me,? Ziebarth said.

The whole time Ziebarth had wanted to remain stoic in the face of the disease. ?The heartburn, the migraines, they were inconsequential compared to the amount of suffering that so many other people go through,? he said.

So it didn?t really hit him until he called his parents and heard their relief.

?For the rest of the day, I was just sort of happy,? Ziebarth said.

If the Internet is any indication, his friends were happy too. Ziebarth?s Facebook status relaying the good news has garnered 427 likes and counting.

?I?m pretty sure it?s the only Facebook status I?ve ever made with more than 10 or 15 likes,? he said. ?It was very touching to see how many people were there for me.?

With peach fuzz now emerging from his scalp, Ziebarth is enjoying the spring semester. He enrolled in five architecture classes and plans to complete a minor in urban design.

The best reward? Ziebarth will use the scholarship money he saved by taking less coursework toward a summer abroad program in Florence, Italy.

?I?ll be living in an apartment down the street from the Duomo,? Ziebarth said. ?Doing studio by day, drinking wine all day and all night.?

Source: http://www.stltoday.com/lifestyles/health-med-fit/washington-university-student-overcomes-testicular-cancer/article_b6ad1271-e074-51a5-a2d8-c2ecae76ee14.html

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Thursday, February 21, 2013

Balsam for the Bones: Chemists develop a nanopaste for the repair of bone defects

Feb. 20, 2013 ? Following accidents or cancer surgery surgeons often have to transplant healthy bone tissue or synthetic material to repair the resulting bone defects. Unfortunately, these procedures do not always have the desired effect.

Now a professor for inorganic chemistry, Matthias Epple was attracted to the interface between biology and medical science. "We have been investigating the impact of mineral tissue such as teeth, bone and sea shells for many years and are now using the knowledge we have gained to produce new biomaterials." To achieve this he has collaborated closely with medical scientists and his current project -- carried out with three of his doctoral students -- was no exception.

"The repair of bone defects presents a real challenge for surgeons," he relates. "When possible they collect the patient's own bone from various locations, such as the iliac crest, and implant it where needed to fill defects." The researcher explained that since there is only a limited amount of surplus bone material in the body, synthetic materials are now being used. "Calcium phosphate is a natural choice here since it is an inorganic mineral found in bones in the form of nanocrystals. It is a material familiar to the body, which makes it a suitable carrier." He added that the calcium and phosphate ions lead to improved new bone formation.

However, the use of synthetic materials creates a host of new problems: the bones heal more slowly, the risk of infection is greater and the mechanical stability is not ideal. Epple's team has now created a bone repair paste by coating synthetic nanocrystals of calcium phosphate with nucleic acids -- in other words, with DNA. The professor explains what happens when this paste is injected into a bone defect: "The nanoparticles are taken up by cells. The calcium phosphate dissolves and the DNA that is released stimulates the formation of two proteins important for healing: BMP-7, which stimulates bone formation, and VEGF-A, which is responsible for the creation of new blood vessels. As a result, the new bone is supplied with valuable nutrients."

The UDE researchers expect that the paste will have a long-lasting effect since the nanoparticles are released successively and thus continuously stimulate the surrounding cells. They have demonstrated that the paste works in three different cell types. Further tests now have to be conducted. Epple and his co-researchers hope that "our development will be used several years from now in the field of traumatology and in the treatment of osteoporosis."

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The above story is reprinted from materials provided by Universit?t Duisburg-Essen.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Svetlana Chernousova, Jan Klesing, Nadia Soklakova, Matthias Epple. A genetically active nano-calcium phosphate paste for bone substitution, encoding the formation of BMP-7 and VEGF-A. RSC Advances, 2013; DOI: 10.1039/C3RA23450A

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/FtM-nJe4qTw/130220100541.htm

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Christ Church

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Christ Church in Malacca, one of the main tourist attractions in Malacca, Malaysia

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